Bacterial fermentation suite
A bioreactor in the cell culture suite
A generous donation from Mr. Gerald A. White in 2006 allowed
for the renovation and expansion of the Bioprocessing laboratory
in the Chemical engineering building. The recent renovations
are substantial: the working area has been more than doubled,
the ventilation system has been expanded and upgraded, new cabinets
with stainless steel countertop have been added along with additional
utility supply lines for the equipment, and a high-grade chemical
and slip resistant floor has been installed.
The area consists of four adjacent but isolated suites (rooms).
The cell culture suite contains two stainless steel steam-in-place
bioreactors, an incubator and laminar flow hood; and is used
to grow Chinese Hamster Ovary (CHO) cells that produce monoclonal
antibodies (mABs). The fermentation suite contains two additional
fermentors, and another incubator and laminar flow hood; and
is used to grow E. Coli cells which produce DNA plasmids. The
cells are separated and lysed, and the bio-products are collected,
in the isolation suite, containing a state-of-the-art; Gaulin
homogenizer, CARR centrifuge and Millipore filter. The general-purpose
suite is used for a variety of larger scale research including
mixing and aeration of bioreactors, purification via chromatography
and other biotechnology projects.