Inoculating a 20 liter bioreactor
Chemical lysis of E. Coli cells
The Biochemical Engineering and BioProcessing lab (BEP),
located in Room 101 of the Chemical Engineering Building, is
engaged in research and education in biochemical engineering
primarily as it relates to the optimization, modeling and scale-up
of biopharmaceutical processes.
Specific areas of interest include growing E. Coli cells
for the production of DNA plasmids for potential use in gene
therapy and DNA vaccine applications, as well as growing Chinese
Hamster Ovary (CHO) cells for production of monoclonal antibodies
BEP, led by Dr. William J. Kelly, associate professor of
Chemical Engineering, was established in the Fall of 2001 and
upgraded in 2006. The lab has equipment capable of growing cells
at the small scale and pilot scale, and has been the home for
10 master's students and over 40 undergraduate researchers.
Members of BEP have worked on numerous collaborative projects
with local pharmaceutical companies such as Johnson & Johnson,
Merck and GlaxoSmithKline (GSK). Most recently, members have
been working collaboratively with GSK researchers to optimize
and model protein recovery via expanded bed chromatography.
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