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    Inoculating a 20 liter bioreactor

    Chemical lysis of E. Coli cells

    The Biochemical Engineering and BioProcessing lab (BEP), located in Room 101 of the Chemical Engineering Building, is engaged in research and education in biochemical engineering primarily as it relates to the optimization, modeling and scale-up of biopharmaceutical processes.

    Specific areas of interest include growing E. Coli cells for the production of DNA plasmids for potential use in gene therapy and DNA vaccine applications, as well as growing Chinese Hamster Ovary (CHO) cells for production of monoclonal antibodies (Mabs).

    BEP, led by Dr. William J. Kelly, associate professor of Chemical Engineering, was established in the Fall of 2001 and upgraded in 2006. The lab has equipment capable of growing cells at the small scale and pilot scale, and has been the home for 10 master's students and over 40 undergraduate researchers. Members of BEP have worked on numerous collaborative projects with local pharmaceutical companies such as Johnson & Johnson, Merck and GlaxoSmithKline (GSK). Most recently, members have been working collaboratively with GSK researchers to optimize and model protein recovery via expanded bed chromatography. We hope you enjoy exploring the website and learning more about us.