|CFD mesh of bioreactor
- top view
Numerical simulations of two phase (gas and liquid) flow
are being pursued using Computational Fluid Dynamic (CFD) modeling.
The simulations predict the breakup and coalescence of gas bubbles
as they are sparged into the bottom of bioreactors and collide
with each other and the spinning impellers. The results of our
CFD model of gas holdup and oxygen transfer in a bioreactor
are being compared to actual experimental data from our laboratory.
The goal of this research is to use the CFD model to determine
the optimum bioreactor configuration (i.e. sparger location
etc…) for given operating conditions (RPM, type cell line..).